How should I take Treximet?
Treximet will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
After taking a Treximet capsule, you must wait two (2) hours before taking a second capsule. Do not take more than 200 mg of sumatriptan capsules in 24 hours.
Store this medicine at room temperature away from moisture and heat.
What is Treximet?
Treximet is a capsule containing a combination of sumatriptan and naproxen.
Sumatriptan is a headache medicine. It is believed to work by narrowing the blood vessels around the brain.
Naproxen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen works by reducing hormones that cause inflammation and pain in the body.
Treximet is used to treat migraine headaches.
Treximet will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Before taking Treximet
You should not use Treximet if you are allergic to sumatriptan (Imitrex), naproxen (Aleve, Anaprox, Naprosyn), or if you have a history of asthma or allergic reaction caused by aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.
Do not take Treximet if you have:
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liver disease;
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untreated or uncontrolled high blood pressure; or
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a history of heart disease, angina (chest pain), blood circulation problems, heart attack, stroke, or heart bypass surgery (also called coronary artery bypass graft, or CABG).
Do not take Treximet if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the past 14 days.
Do not take Treximet within 24 hours before or after taking any of the following medicines:
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almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex), or zolmitriptan (Zomig); or
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ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).
If you any of these other conditions, you may need a dose adjustment or special tests to safely use Treximet:
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epilepsy or other seizure disorder;
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kidney disease;
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high blood pressure, congestive heart failure; or
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coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).
FDA pregnancy category C. Taking naproxen during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Sumatriptan and naproxen can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking Treximet.
